INSULIN-DEPENDENT DIABETES-MELLITUS HYPOTHESIS OF AUTOIMMUNITY

被引：19

作者：

ROSSINI, AA

HANDLER, ES

GREINER, DL

MORDES, JP

机构：

[1] Department of Medicine, University of Massachusetts Medical School, Worcester, MA

[2] Department of Pathology, University of Connecticut Health Science Center, Farmington, CT

来源：

AUTOIMMUNITY | 1991年 / 8卷 / 03期

关键词：

D O I：

10.3109/08916939108997110

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Diabetes mellitus, a disorder of hyperglycemia recognized for centuries by its classical symptoms of polyuria and polydipsia, affects about 5% of the population in Western nations. Among many diabetic syndromes now recognized, insulin dependent diabetes mellitus (IDDM, Type I) and non-insulin dependent diabetes mellitus (NIDDM, Type II) are by far the most common1. IDDM accounts for ≊ 10% of all cases of diabetes and characteristically appears in children, whereas NIDDM is primarily a disorder of obese adults. A growing consensus supports the hypothesis that IDDM is a disorder of autoimmunity2-4. Evidence supporting this view falls into several broad categories. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：221 / 235

页数：15

共 169 条

[1]

Classification and diagnosis of diabetes mellitus and other- categories of glucose intoler ance, Diabetes, 28, pp. 1039-1057, (1979)

[2]

Bach J.F., Mechanisms of autoimmunity in insulin-dependent diabetes mellitus, Clin Exp Immunol, 72, pp. 1-8, (1988)

[3]

Hitchcock C.L., Riley W.J., Maclaren N.K., Autoimmunity in insulin-dependent diabetes mellitus: its detection and prevention, Concepts Immunopathol, 5, pp. 144-167, (1988)

[4]

Cohen I.R., Insulin-dependent diabetes mellitus, Curr Opinion Immunol, 1, pp. 727-732, (1989)

[5]

Gepts W., Pathology and anatomy of the pancreas in juvenile diabetes mellitus, Diabetes, 14, pp. 619-633, (1965)

[6]

Bottazzo G.F., Dean B.M., McNally J.M., MacKay E.H., Swift P.G.F., Gamble D.R., In Situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis, N Engl J Med, 313, pp. 353-360, (1985)

[7]

Sibley R.K., Sutherland D.E., Goetz F., Michael A.F., Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases, Lab Invest, 53, pp. 132-144, (1985)

[8]

Pozzilli P., Zuccarini O., Iavicoli M., Andreani D., Sensi M., Spencer K.M., Et al., Monoclonal antibodies defined abnormalities of T-lymphocytes in type 1 (Insulin-dependent) diabetes, Diabetes, 32, pp. 91-94, (1983)

[9]

Lederman M.M., Ellner J.J., Rodman H.M., Defective suppressor cell generation in juvenile onset diabetes, J lmmunol, 127, pp. 2051-2055, (1981)

[10]

Quiniou-Debrie M.C., Debray-Sachs M., Dardenne M., Czernichow P., Assan R., Bach J.F., Anti-islet cellular and humoral immunity, T-cell subsets, and thymic function in Type 1 diabetes, Diabetes, 34, pp. 373-379, (1985)

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