BLOCKING OF BACTERICIDAL KILLING OF NEISSERIA-MENINGITIDIS BY ANTIBODIES DIRECTED AGAINST CLASS-4 OUTER-MEMBRANE PROTEIN

被引：51

作者：

MUNKLEY, A ^{[1
]}

TINSLEY, CR ^{[1
]}

VIRJI, M ^{[1
]}

HECKELS, JE ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,SOUTHAMPTON GEN HOSP,SCH MED,DEPT MICROBIOL,SOUTHAMPTON S09 4XY,ENGLAND

来源：

MICROBIAL PATHOGENESIS | 1991年 / 11卷 / 06期

基金：

英国医学研究理事会;

关键词：

NEISSERIA-MENINGITIDIS; VACCINE; BLOCKING ANTIBODIES; BACTERICIDAL KILLING; COMPLEMENT; OUTER MEMBRANE PROTEINS;

D O I：

10.1016/0882-4010(91)90041-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The class 4 protein of Neisseria meningitidisis is a highly conserved outer membrane protein, closely related to the protein PIII of Neisseria gonorrhoea. Monoclonal antibodies SM50 and SM54 raised against PIII also react with class 4 protein but do not promote complement mediated bactericidal killing of meningococci. In addition, mAb SM50 inhibits the antimeningococcal bactericidal activity both of normal human sera and of mAb SM300, directed against a protective epitope on the class 1 outer membrane protein. The ability of class 4 protein to induce such 'blocking' antibodies suggests that its presence in experimental vaccines, based on meningococcal outer membranes, may be antagonistic to the development of effective bactericidal immunity. © 1991.

引用

页码：447 / 452

页数：6

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