MOLECULAR-GENETICS OF PESTIVIRUSES

被引：88

作者：

COLLETT, MS

机构：

[1] MedImmune Inc., Gaithersburg, MD 20878

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 1992年 / 15卷 / 03期

关键词：

PESTIVIRUS; MOLECULAR BIOLOGY; VIRAL GENOME; VIRAL PROTEINS; GENE EXPRESSION; POLYPROTEIN PROCESSING; VIRAL PROTEINASES; PROTEIN FUNCTIONS; FLAVIVIRUSES; HUMAN HEPATITIS-C VIRUSES;

D O I：

10.1016/0147-9571(92)90087-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent developments in understanding the molecular genetics of pestiviruses are reviewed. The genomic RNA of several pestiviruses has been molecularly cloned and sequenced. The genetic organization of the viral protein coding region has been refined, and the complete complement of virus-encoded proteins has been elucidated. Viral gene expression involves both co-translational and post-translational precursor polyprotein processing. Biogenesis of the virion structural proteins requires the proteolytic activity of the first protein of the open reading frame (p20), as well as host cell enzymes. A second virus-encoded proteinase (p80) is required for processing viral nonstructural proteins. Molecular and biochemical data indicate pestiviruses share many features with both the flaviviruses and human hepatitis C viruses, while at the same time, also reveal their distinct nature.

引用

收藏

页码：145 / 154

页数：10

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