HLA POLYMORPHISM AND T-CELL RECOGNITION OF A CONSERVED REGION OF P190, A MALARIA VACCINE CANDIDATE

被引：27

作者：

GUTTINGER, M ^{[1
]}

ROMAGNOLI, P ^{[1
]}

VANDEL, L ^{[1
]}

MELOEN, R ^{[1
]}

TAKACS, B ^{[1
]}

PINK, JRL ^{[1
]}

SINIGAGLIA, F ^{[1
]}

机构：

[1] CENT VET INST, LELYSTAD, NETHERLANDS

来源：

INTERNATIONAL IMMUNOLOGY | 1991年 / 3卷 / 09期

关键词：

PLASMODIUM-FALCIPARUM; MHC-RESTRICTION; HUMAN T-CELL CLONES; T-CELL EPITOPES; PEPTIDE BINDING;

D O I：

10.1093/intimm/3.9.899

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have examined T cell recognition of a recombinant polypeptide (190L), corresponding to a 175-amino-acid-long conserved region of the major surface antigen (p190) of Plasmodium falciparum merozoites. We show that 190L contains a variety of T cell epitopes, and can be recognized in association with many different MHC class II molecules, including HLA-DR, DP, and DQ antigens. Most of the epitope-containing peptides are able to bind to more than one DR, and a single DR molecule can bind to different peptides. These findings, together with the fact that humans are generally heterozygous at the DR, DQ, and DP beta-chain loci, suggest that MHC restriction should not be a major constraint in the development of malaria subunit vaccines.

引用

页码：899 / 906

页数：8

共 39 条

[1] MECHANISMS INFLUENCING THE IMMUNODOMINANCE OF T-CELL DETERMINANTS [J].