USE OF HIGH-DOSE FLUCONAZOLE AS SALVAGE THERAPY FOR CRYPTOCOCCAL MENINGITIS IN PATIENTS WITH AIDS

被引：66

作者：

BERRY, AJ ^{[1
]}

RINALDI, MG ^{[1
]}

GRAYBILL, JR ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 03期

关键词：

D O I：

10.1128/AAC.36.3.690

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Eight patients with AIDS were treated orally with 800 mg of fluconazole daily for cryptococcal meningitis for a mean duration of 4.5 months. Previous antifungal treatment had failed for all of the patients. No major toxicity was observed. Three patients died from cryptococcal infection. High-dose fluconazole may be effective salvage therapy for cryptococcal meningitis.

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页码：690 / 692

页数：3

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