MACROPHAGE COLONY STIMULATING FACTOR PREVENTS THE PROGRESSION OF ATHEROSCLEROSIS IN WATANABE HERITABLE HYPERLIPIDEMIC RABBITS

被引:67
作者
INOUE, I
INABA, T
MOTOYOSHI, K
HARADA, K
SHIMANO, H
KAWAMURA, M
GOTODA, T
OKA, T
SHIOMI, M
WATANABE, Y
TSUKADA, T
YAZAKI, Y
TAKAKU, F
YAMADA, N
机构
[1] UNIV TOKYO,DEPT INTERNAL MED 3,TOKYO 113,JAPAN
[2] UNIV TOKYO,DEPT PATHOL,TOKYO 113,JAPAN
[3] KOBE UNIV,SCH MED,INST EXPTL ANIM,KOBE 650,JAPAN
[4] SANRAKU HOSP,TOKYO,JAPAN
关键词
M-CSF; MACROPHAGE; CYTOKINE; FOAM CELL; WHHL RABBIT;
D O I
10.1016/0021-9150(92)90261-E
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The early atherosclerotic lesion is characterized by the presence of macrophage-derived foam cells. Macrophage colony stimulating factor (M-CSF) specifically stimulates the functions of the monocyte-macrophages. To elucidate the effects of M-CSF in the atherogenic process in vivo, we administered human recombinant M-CSF into Watanabe heritable hyperlipidemic (WHHL) rabbits, an animal model for familial hypercholesterolemia. Three hundred micrograms of M-CSF were intravenously injected into WHHL rabbits aged 2.5 months, three times a week for 8.5 months. After the M-CSF treatment, we found very retarded progression of atherosclerosis. The accumulation of cholesterol ester was remarkably decreased in the aortae of M-CSF-treated animals (0.60 +/- 0.32 mg/g tissue), as compared to those of controls (4.32 +/- 0.61 mg/g tissue). Furthermore, the percentage of the surface area of the aorta with macroscopic plaque in animals treated with M-CSF was 14.3 +/- 6.2%, much less than that in controls receiving saline injection (38.8 +/- 8.0%). Thus, M-CSF definitely prevented the progression of atherosclerosis in WHHL rabbits by influencing macrophage functions.
引用
收藏
页码:245 / 254
页数:10
相关论文
共 31 条
[1]  
ALLAIN CC, 1974, CLIN CHEM, V20, P470
[2]   A RECEPTOR-MEDIATED PATHWAY FOR CHOLESTEROL HOMEOSTASIS [J].
BROWN, MS ;
GOLDSTEIN, JL .
SCIENCE, 1986, 232 (4746) :34-47
[3]  
BUCOLO G, 1973, CLIN CHEM, V19, P476
[5]   THE HUMAN HEMATOPOIETIC COLONY-STIMULATING FACTORS [J].
CLARK, SC ;
KAMEN, R .
SCIENCE, 1987, 236 (4806) :1229-1237
[6]   MACROPHAGE COLONY STIMULATING FACTOR RESTORES INVIVO BONE-RESORPTION IN THE OP/OP OSTEOPETROTIC MOUSE [J].
FELIX, R ;
CECCHINI, MG ;
FLEISCH, H .
ENDOCRINOLOGY, 1990, 127 (05) :2592-2594
[7]  
FONG LG, 1990, J BIOL CHEM, V265, P11751
[8]   HYPERTRIGLYCERIDEMIC VERY LOW-DENSITY LIPOPROTEINS INDUCE TRIGLYCERIDE SYNTHESIS AND ACCUMULATION IN MOUSE PERITONEAL-MACROPHAGES [J].
GIANTURCO, SH ;
BRADLEY, WA ;
GOTTO, AM ;
MORRISETT, JD ;
PEAVY, DL .
JOURNAL OF CLINICAL INVESTIGATION, 1982, 70 (01) :168-178
[9]   IMMUNE-MECHANISMS IN ATHEROSCLEROSIS [J].
HANSSON, GK ;
JONASSON, L ;
SEIFERT, PS ;
STEMME, S .
ARTERIOSCLEROSIS, 1989, 9 (05) :567-578
[10]   DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM [J].
HAVEL, RJ ;
EDER, HA ;
BRAGDON, JH .
JOURNAL OF CLINICAL INVESTIGATION, 1955, 34 (09) :1345-1353