PROLACTIN RESPONSE TO DL-FENFLURAMINE IN PANIC DISORDER

被引：23

作者：

APOSTOLOPOULOS, M ^{[1
]}

JUDD, FK ^{[1
]}

BURROWS, GD ^{[1
]}

NORMAN, TR ^{[1
]}

机构：

[1] UNIV MELBOURNE,AUSTIN HOSP,DEPT PSYCHIAT,HEIDELBERG,VIC 3084,AUSTRALIA

来源：

PSYCHONEUROENDOCRINOLOGY | 1993年 / 18卷 / 5-6期

关键词：

D O I：

10.1016/0306-4530(93)90009-A

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objective of this study was to test the hypothesis that serotonin receptors are hypersensitive in patients with panic disorder. Eleven patients and 12 controls received a single PO dose of 60 mg of dl-fenfluramine at 0900h on a single occasion. Blood samples were collected with an indwelling intravenous catheter at 30-min intervals from 0930h to 1530h and prolactin determined by radioimmunoassay. In both groups, fenfluramine induced a rise in the plasma prolactin concentration from baseline. The patients showed a greater increase in prolactin response than the normal controls. This result is consistent with the hypothesis of increased serotonin receptor function in patients with panic disorder.

引用

页码：337 / 342

页数：6

共 21 条

[1] SEROTONIN FUNCTION IN ANXIETY .2. EFFECTS OF THE SEROTONIN AGONIST MCPP IN PANIC DISORDER PATIENTS AND HEALTHY-SUBJECTS
CHARNEY, DS
WOODS, SW
GOODMAN, WK
HENINGER, GR
[J]. PSYCHOPHARMACOLOGY, 1987, 92 (01) : 14 - 24
[2] COWEN PJ, 1987, ARCH GEN PSYCHIAT, V44, P959
[3] EFFECT OF A SEROTONIN AND NORADRENALINE UPTAKE INHIBITOR IN PANIC DISORDER - A DOUBLE-BLIND COMPARATIVE-STUDY WITH FLUVOXAMINE AND MAPROTILINE
DENBOER, JA
WESTENBERG, HGM
[J]. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1988, 3 (01) : 59 - 74
[4] EFFECT OF A SELECTIVE SEROTONIN UPTAKE INHIBITOR IN AGORAPHOBIA WITH PANIC ATTACKS - A DOUBLE-BLIND COMPARISON OF ZIMELDINE, IMIPRAMINE AND PLACEBO
EVANS, L
KENARDY, J
SCHNEIDER, P
HOEY, H
[J]. ACTA PSYCHIATRICA SCANDINAVICA, 1986, 73 (01) : 49 - 53
[5] FUXE K, 1975, POSTGRAD MED J, V51, P35
[6] GORMAN JM, 1987, J CLIN PSYCHOPHARM, V7, P329
[7] D-ISOMERS AND L-ISOMERS OF FENFLURAMINE DIFFER MARKEDLY IN THEIR INTERACTION WITH BRAIN-SEROTONIN AND CATECHOLAMINES IN THE RAT
INVERNIZZI, R
BERETTERA, C
GARATTINI, S
SAMANIN, R
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 120 (01) : 9 - 15
[8] THE MCPP CHALLENGE TEST IN SCHIZOPHRENIA - HORMONAL AND BEHAVIORAL-RESPONSES
IQBAL, N
ASNIS, GM
WETZLER, S
KAHN, RS
KAY, SR
VANPRAAG, HM
[J]. BIOLOGICAL PSYCHIATRY, 1991, 30 (08) : 770 - 778
[9] BEHAVIORAL INDICATIONS FOR SEROTONIN RECEPTOR HYPERSENSITIVITY IN PANIC DISORDER
KAHN, RS
WETZLER, S
VANPRAAG, HM
ASNIS, GM
STRAUMAN, T
[J]. PSYCHIATRY RESEARCH, 1988, 25 (01) : 101 - 104
[10] L-5-HYDROXYTRYPTOPHAN IN THE TREATMENT OF ANXIETY DISORDERS
KAHN, RS
WESTENBERG, HGM
[J]. JOURNAL OF AFFECTIVE DISORDERS, 1985, 8 (02) : 197 - 200

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