ABSENCE OF TOXICITY IN PATIENTS WITH MALIGNANT OTITIS-EXTERNA FOLLOWING LONG-TERM TREATMENT WITH HIGH DOSAGE TOBRAMYCIN

被引：9

作者：

IOANNIDESDEMOS, LL

LI, SC

BASTONE, EB

SPELMAN, DW

HOOPER, RE

COUSINS, VC

MCLEAN, AJ

机构：

[1] MONASH UNIV,ALFRED HOSP,DEPT CLIN PHARMACOL,MELBOURNE,VIC 3181,AUSTRALIA

[2] MONASH UNIV,ALFRED HOSP,DEPT PHARM,MELBOURNE,VIC 3181,AUSTRALIA

[3] MONASH UNIV,ALFRED HOSP,DEPT MICROBIOL & INFECT DIS,MELBOURNE,VIC 3181,AUSTRALIA

[4] MONASH UNIV,ALFRED HOSP,DEPT OTOLARYNGOL,MELBOURNE,VIC 3181,AUSTRALIA

[5] MONASH UNIV,ALFRED HOSP,DEPT MED,MELBOURNE,VIC 3181,AUSTRALIA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1994年 / 34卷 / 02期

关键词：

D O I：

10.1093/jac/34.2.267

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

An in-vitro model of aminoglycoside dosing was used to demonstrate that the bactericidal activity of tobramycin against Pseudomonas aeruginosa is directly related to the peak concentration of the drug. In addition, six patients who were being treated for malignant otitis externa with long-term, high dosage tobramycin were monitored for oto- and nephro-toxicity; the only adverse effects were transient increases in the serum creatinine concentration in two patients. © 1994 The British Society for Antimicrobial Chemotherapy.

引用

页码：267 / 274

页数：8

共 12 条

[1] KILL KINETICS AND REGROWTH PATTERNS OF ESCHERICHIA-COLI EXPOSED TO GENTAMICIN CONCENTRATION-TIME PROFILES SIMULATING INVIVO BOLUS AND INFUSION DOSING [J].