SOLUBLE C-ERBB-2 FRAGMENT IN SERUM CORRELATES WITH DISEASE STAGE AND PREDICTS FOR SHORTENED SURVIVAL IN PATIENTS WITH EARLY-STAGE AND ADVANCED BREAST-CANCER

被引：80

作者：

KANDL, H ^{[1
]}

SEYMOUR, L ^{[1
]}

BEZWODA, WR ^{[1
]}

机构：

[1] UNIV WITWATERSRAND,SCH MED,DEPT MED,DIV CLI HAEMATOL & MED ONCOL,JOHANNESBURG 2193,SOUTH AFRICA

来源：

BRITISH JOURNAL OF CANCER | 1994年 / 70卷 / 04期

关键词：

D O I：

10.1038/bjc.1994.387

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Seventy-nine patients with advanced breast cancer were tested for the presence, in serum, of a 110 kDa soluble, c-erbB-2 fragment. Thirty-nine patients were seropositive. There was no correlation between seropositivity and menopausal status, or with oestrogen status. In addition, no correlation could be found between tissue c-erbB-2 immunostaining for the external domain of the c-erbB-2 receptor and the presence of soluble c-erbB-2 in serum. The presence of serum soluble c-erbB-2, however, had a significant impact on survival of patients with advanced disease, suggesting that this test may become a useful independent prognostic indicator.

引用

页码：739 / 742

页数：4

共 23 条

[1]

ALLRED DC, 1992, J CLIN ONCOL, V10, P1049

[2]

BORG A, 1990, CANCER RES, V50, P4332

[3]

CLARK GM, 1991, CANCER RES, V51, P944

[4]

CLINE M, 1987, J CLIN ONCOL, V7, P999

[5]

GUSTERSON BA, 1992, J CLIN ONCOL, V10, P599

[6] NONPARAMETRIC-ESTIMATION FROM INCOMPLETE OBSERVATIONS [J].

KAPLAN, EL ;

MEIER, P .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1958, 53 (282) :457-481

[7]

LANGTON BC, 1991, CANCER RES, V51, P2593

[8] ELEVATED SOLUBLE C-ERBB-2 ANTIGEN LEVELS IN THE SERUM AND EFFUSIONS OF A PROPORTION OF BREAST-CANCER PATIENTS [J].

LEITZEL, K ;

TERAMOTO, Y ;

SAMPSON, E ;

MAUCERI, J ;

LANGTON, BC ;

DEMERS, L ;

PODCZASKI, E ;

HARVEY, H ;

SHAMBAUGH, S ;

VOLAS, G ;

WEAVER, S ;

LIPTON, A .

JOURNAL OF CLINICAL ONCOLOGY, 1992, 10 (09) :1436-1443

[9]

MAGUIRE HC, 1992, PATHOBIOLOGY, V60, P117

[10]

MAGUIRE HC, 1989, SEMIN ONCOL, V16, P148

← 1 2 3 →