INDUCTION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION IN SYNOVIAL FIBROBLASTS BY PROSTAGLANDIN-E AND INTERLEUKIN-1 - A POTENTIAL MECHANISM FOR INFLAMMATORY ANGIOGENESIS

被引：439

作者：

BENAV, P

CROFFORD, LJ

WILDER, RL

HLA, T

机构：

[1] AMER RED CROSS,JEROME H HOLLAND LAB,DEPT BIOL MOLEC,ROCKVILLE,MD 20855

[2] UNIV MICHIGAN,SCH MED,DEPT INTERNAL MED,DIV RHEUMATOL,ANN ARBOR,MI

[3] NIAMS,BETHESDA,MD

来源：

FEBS LETTERS | 1995年 / 372卷 / 01期

关键词：

ANGIOGENESIS; INTERLEUKIN-1-ALPHA; PROSTAGLANDIN E(2); RHEUMATOID ARTHRITIS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

D O I：

10.1016/0014-5793(95)00956-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammatory mediators such as prostaglandin E(2) (PGE(2)) and interleukin-l (IL-1) induce angiogenesis by yet undefined mechanisms, We demonstrate that PGE(2) and IL-1 induces the expression of vascular endothelial growth factor (VEGF), a selective angiogenic factor by rheumatoid synovial fibroblast cells, Transcripts for the EP(1) and EP(2) subtypes of PGE receptors are expressed in synovial fibroblasts, Activators of protein kinase A pathway stimulated the expression of VEGF whereas down-regulation of protein kinase C did not influence the PGE effect, suggesting that signalling from the EP(2) receptor via the protein kinase A pathway is important, The induction of VEGF expression by PGE(2) and interleukin-1 alpha may be an important mechanism in inflammatory angiogenesis.

引用

页码：83 / 87

页数：5

共 45 条

[1] CLONING AND EXPRESSION OF 3 ISOFORMS OF THE HUMAN EP(3) PROSTANOID RECEPTOR [J].