CARDIOVASCULAR EFFECTS OF INFUSION OF LIDOCAINE ON PATIENTS WITH HEART DISEASE

被引:71
作者
GROSSMAN, JI
COOPER, JA
FRIEDEN, J
机构
关键词
D O I
10.1016/0002-9149(69)90403-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The cardiovascular effects of constant infusion of lidocaine were determined during right heart catheterization in 10 unanesthetized patients with significant myocardial disease. Three patients were receiving digitalis. A 1.5 mg./kg. bolus or a brief infusion of 300 μg./kg. per min., followed in each instance by a 50 μg./kg. per min. (3 to 3.5 mg./min.) infusion, was used. Atrial or ventricular pacing, or both, was utilized in 5 patients to obviate cardiovascular changes resulting from varying rates or rhythms. Atrioventricular conduction time measured in 4 instances did not change. Radioactive lidocaine plasma levels, determined in 4 patients, were in a therapeutic range of 1.5 to 5.5 μg./ml. Little change in heart rate, intracardiac or systemic arterial pressures, or myocardial contractility occurred. No significant decrease in cardiac output was noted. Significant increases in cardiac output occurred in 3 of the 4 studies in which lidocaine terminated frequent ventricular extrasystoles. No adverse hemodynamic effects of continuous infusion of lidocaine were observed. © 1969.
引用
收藏
页码:191 / &
相关论文
共 30 条
[1]   INFLUENCE OF QUINIDINE AND PROCAINE AMIDE ON MYOCARDIAL CONTRACTILITY INVIVO [J].
ANGELAKOS, ET ;
HASTINGS, EP .
AMERICAN JOURNAL OF CARDIOLOGY, 1960, 5 (06) :791-798
[2]   ASSESSMENT OF MYOCARDIAL DEPRESSION WITH THERAPEUTIC DOSES OF LIDOCAINE AND PROCAINAMIDE [J].
ASOKAN, SK ;
FRANK, MJ ;
REGAN, TJ .
AMERICAN JOURNAL OF CARDIOLOGY, 1968, 21 (01) :91-&
[3]   CARDIAC AND PERIPHERAL VASCULAR EFFECTS OF LIDOCAINE AND PROCAINAMIDE [J].
AUSTEN, WG ;
MORAN, JM .
AMERICAN JOURNAL OF CARDIOLOGY, 1965, 16 (05) :701-&
[4]   HEMODYNAMIC CONSEQUENCES OF ATRIAL AND VENTRICULAR ARRHYTHMIAS IN MAN [J].
BENCHIMOL, A ;
ELLIS, JG ;
DIMOND, EG ;
WU, TL .
AMERICAN HEART JOURNAL, 1965, 70 (06) :775-+
[5]  
CONSTANTINO RT, 1967, CIRCULATION S2, V36, P89
[6]  
D'AMATO H E, 1955, Arch Int Pharmacodyn Ther, V101, P113
[7]  
FOLDES FF, 1965, CLIN PHARMACOL THER, V6, P328
[8]  
FOLLE LE, 1966, J PHARMACOL EXP THER, V154, P92
[9]  
FRIEDBERG CK, 1966, DISEASES HEART, P509
[10]   ANTIARRHYTHMIC DRUGS .7. LIDOCAINE AS AN ANTIARRHYTHMIC AGENT [J].
FRIEDEN, J .
AMERICAN HEART JOURNAL, 1965, 70 (05) :713-&