INTESTINAL HANDLING OF 2 TETRAPEPTIDES BY RODENT SMALL-INTESTINE INVITRO

被引：24

作者：

BURSTON, D

TAYLOR, E

MATTHEWS, DM

机构：

[1] Department of Experimental Chemical Pathology, Vincent Square Laboratories, Westminster Hospital, London

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 553卷 / 01期

基金：

英国医学研究理事会;

关键词：

(Jejunum); Intestinal transport; Tetrapeptide absorption;

D O I：

10.1016/0005-2736(79)90039-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Uptake of free Leu and Ala and uptake of these amino acids from the tetrapeptides Leu-Gly-Gly-Gly and Ala-Gly-Gly-Gly has been studied in rings of everted rodent jejunum in vitro. When mediated uptake of free Leu was virtually saturated addition of Leu-Gly-Gly-Gly gave no significant increase in uptake of Leu. Uptake of Leu and of Ala from the tetrapeptides was strongly inhibited by Met, as was uptake of these amino acids from free solution. The results did not suggest that either tetrapeptide was taken up intact by the jejunum. © 1979.

引用

页码：175 / 178

页数：4

共 15 条

[1]

NUMBER OF GLYCINE RESIDUES WHICH LIMITS INTACT ABSORPTION OF GLYCINE OLIGOPEPTIDES IN HUMAN JEJUNUM [J].