GASTROINTESTINAL TRANSIT AND RELEASE OF MESALAZINE TABLETS IN PATIENTS WITH INFLAMMATORY BOWEL-DISEASE

被引：19

作者：

HEALEY, JNC

机构：

[1] Smith Kline and French Laboratories Ltd., Welwyn Garden City, Hertfordshire

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1990年 / 25卷

关键词：

Colitis; Crohn's disease; Delayed-release tablets; Inflammatory bowel disease; Mesalazine;

D O I：

10.3109/00365529009091910

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Gastrointestinal transit and release of a delayed-release, enteric-coated tablet of mesalazine (Claversal) were studied in 13 patients with Crohn's disease and ulcerative colitis. The tablets disintegrated a mean of 3.2 h after leaving the stomach, resulting in drug dispersion in the distal small intestine or proximal colon. Tablet disintegration closely correlated with onset of drug absorption. Peak mean concentrations of mesalazine and its main metabolite, Ac-5-ASA, were 0.5 μg/ml and 1.0μg/ml, respectively, and occurred 3 to 4h after gastric emptying. The plasma levels correlated with scintigraph images of tablet disintegration. It is concluded that the tablets effectively deliver mesalazine to the terminal ileum and proximal colon in patients with inflammatory bowel disease. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：47 / 51

页数：5

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