DEGRADATION OF MYELIN BASIC-PROTEIN BY CEREBROSPINAL-FLUID - PRESERVATION OF ANTIGENIC DETERMINANTS UNDER PHYSIOLOGICAL CONDITIONS

被引：30

作者：

ALVORD, EC

HRUBY, S

SIRES, LR

机构：

[1] Laboratory of Neuropathology, University of Washington Medical School, Seattle, Washington

来源：

ANNALS OF NEUROLOGY | 1979年 / 6卷 / 06期

关键词：

D O I：

10.1002/ana.410060604

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebrospinal fluid contains several proteolytic enzymes that can degrade myelin basic protein (BP) under physiological conditions into peptide fragments of various sizes which still contain antigenic determinants capable of binding antibodies to BP. These enzymes are optimally active in either acid (pH 4) or neutral (pH 7 to 8) conditions and can be characterized by the nature of the BP peptide fragments produced. Proteinases resembling cathepsin D, thrombin, plasmin (fibrinolysin), or kallikrein are present in variable amounts in CSF. No relatinship to any particular disease has yet been established. Copyright © 1979 American Neurological Association

引用

页码：474 / 482

页数：9

共 52 条

[1]

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[2]

ALVORD EC, 1977, SLOW VIRUS INFECTION, P166

[3]

ALVORD EC, 1976, AETIOLOGY PATHOGENES, P217

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