THIOL-DEPENDENT METALLO-ENDOPEPTIDASE CHARACTERISTICS OF PZ-PEPTIDASE IN RAT AND RABBIT

被引：29

作者：

TISLJAR, U

BARRETT, AJ

机构：

来源：

BIOCHEMICAL JOURNAL | 1990年 / 267卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1042/bj2670531

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pz-peptidase was purified from rat testis and rabbit muscle. Zinc was detectable in the rat enzyme. The activity of the enzyme from both species was slowly but completely abolished by EDTA and restored by Zn2+. Free thiol groups were also important for the catalytic activity of rat Pz-peptidase, as previously reported for the rabbit enzyme. We conclude that in both species Pz-peptidase has the characteristics of a thiol-dependent metallo-endopeptidase.

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页码：531 / 533

页数：3

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