COMPARABLE SENSITIVITY OF HAIRLESS AND HARTLEY STRAIN GUINEA-PIGS TO A PRIMARY IRRITANT AND A SENSITIZER

被引：4

作者：

BUEHLER, EV ^{[1
]}

KREUZMANN, JJ ^{[1
]}

SAKR, A ^{[1
]}

GU, XH ^{[1
]}

机构：

[1] UNIV CINCINNATI,MED CTR,CINCINNATI,OH 45267

来源：

JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY | 1990年 / 9卷 / 03期

关键词：

D O I：

10.3109/15569529009036322

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

A hairless mutant guinea pig (crl:IAF/HA[hr/hr]BR) has recently been developed that could be useful for the study and evaluation of primary irritants and contact sensitizers. The quality of responses in this new strain was therefore compared to the standard Hartley strain animal. Two standard procedures commonly utilized for risk assessment were selected. Dose-response experiments were designed to evaluate a full range of dermal responses. It was determined that the hairless guinea pig is more susceptible to both a primary irritant and a contact sensitizer as determined by use of the guinea pig immersion and Buehler methodologies. The results, in terms of risk evaluation, are discussed. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：163 / 168

页数：6

共 9 条

[1]

ANDERSON KE, 1985, CURR PROBL DERMATOL, V14

[2]

Buehler E.V., 1985, IMMUNOTOXICOLOGY IMM, P123

[3]

DELAYED CONTACT HYPERSENSITIVITY IN GUINEA PIG [J].