INVOLVEMENT OF PERTUSSIS TOXIN-SENSITIVE GTP-BINDING PROTEIN IN PROSTAGLANDIN-F2-ALPHA-INDUCED PHOSPHOINOSITIDE HYDROLYSIS IN OSTEOBLAST-LIKE CELLS

被引：47

作者：

MIWA, M ^{[1
]}

TOKUDA, H ^{[1
]}

TSUSHITA, K ^{[1
]}

KOTOYORI, J ^{[1
]}

TAKAHASHI, Y ^{[1
]}

OZAKI, N ^{[1
]}

KOZAWA, O ^{[1
]}

OISO, Y ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH MED,DEPT INTERNAL MED 1,NAGOYA,AICHI 466,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)90817-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostaglandin F2α (PGF2α) stimulated the formation of inositol phosphates in a dose-dependent manner in cloned osteoblast-like MC3T3-E1 cells. This reaction was markedly inhibited dose-dependently by pertussis toxin. In the cell membranes, pertussis toxin-catalyzed ADP-ribosylation of a 40-kDa protein was significantly attenuated by pretreatment of PGF2α. These results suggest that pertussis toxin-sensitive GTP-binding protein is involved in the coupling of PGF2α receptor to phospholipase C in these cells. © 1990.

引用

页码：1229 / 1235

页数：7

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