ISOLATION OF L-3-PHENYLLACTYL-PHE-LYS-ALA-NH2 (ANTHO-KAAMIDE), A NOVEL NEUROPEPTIDE FROM SEA-ANEMONES

被引:9
作者
NOTHACKER, HP [1 ]
RINEHART, KL [1 ]
GRIMMELIKHUIJZEN, CJP [1 ]
机构
[1] UNIV ILLINOIS,SCH CHEM SCI,URBANA,IL 61801
关键词
D O I
10.1016/0006-291X(91)91700-M
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have isolated and sequenced the neuropeptide L-3-phenyllactyl-Phe-Lys-Ala-NH2 from the sea anemone Anthopleura elegantissima. This neuropeptide (named Antho-KAamide) has the unusual N-terminal L-3-phenyllactyl blocking group which has recently also been discovered in 2 other neuropeptides from sea anemones. We propose that the L-3-phenyllactyl residue renders Antho-KAamide resistant to nonspecific aminopeptidases, thereby increasing the stability of the neuropeptide after neuronal release. The existence of the L-3-phenyllactyl residue in 3 neuropeptides isolated so far suggests that this blocking group is more generally occurring. © 1991.
引用
收藏
页码:1205 / 1211
页数:7
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