CONFORMATION OF HISTAMINE DERIVATIVES .3. RELATIONSHIP BETWEEN CONFORMATION AND PHARMACOLOGICAL ACTIVITY

被引：83

作者：

GANELLIN, CR ^{[1
]}

机构：

[1] SK&F,RES INST,WELWYN GARDEN CITY,HERTFORDSHIRE,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1973年 / 16卷 / 06期

关键词：

D O I：

10.1021/jm00264a009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：620 / 623

页数：4

共 11 条

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[3] CONFORMATION OF HISTAMINE DERIVATIVES .2. MOLECULAR-ORBITAL CALCULATIONS OF PREFERRED CONFORMATIONS IN RELATION TO DUAL RECEPTOR ACTIVITY [J].

GANELLIN, CR ;

PORT, GNJ ;

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JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (06) :616-620

[4] CONFORMATION OF HISTAMINE DERIVATIVES .1. APPLICATION OF MOLECULAR-ORBITAL CALCULATIONS AND NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY [J].

GANELLIN, CR ;

PEPPER, ES ;

PORT, GNJ ;

RICHARDS, WG .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (06) :610-616

[5] STRUCTURAL INFLUENCES UPON ANTIHISTAMINE ACTIVITY - 3-AMINO-1-ARYL-1-(2-PYRIDYL)PROPENES AND RELATED COMPOUNDS [J].

ISON, RR ;

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[6] MOLECULAR ORBITAL CALCULATIONS OF PREFERRED CONFORMATIONS OF HISTAMINE AND A THEORY ON ITS DUAL ACTIVITY [J].

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[7]

LEE HM, 1949, J PHARMACOL EXP THER, V95, P71

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[9] TRANSLOCATION OF LIGAND CONFORMATIONAL FREE ENERGY IN RECEPTOR ACTIVATION - POSSIBLE FUNCTIONAL ROLE OF CONFORMATIONAL ISOMERISM IN DRUG ACTION [J].

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[10]

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