NMDA RECEPTOR INHIBITION PREVENTS TOLERANCE TO COCAINE

被引：45

作者：

DEMONTIS, MG ^{[1
]}

DEVOTO, P ^{[1
]}

MELONI, D ^{[1
]}

GAMBARANA, C ^{[1
]}

GIORGI, G ^{[1
]}

TAGLIAMONTE, A ^{[1
]}

机构：

[1] UNIV CAGLIARI,DEPT NEUROSCI,I-09124 CAGLIARI,ITALY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 42卷 / 01期

关键词：

CENTRAL STIMULANTS; TOLERANCE; NMDA RECEPTOR ANTAGONISTS; BEHAVIORAL SENSITIZATION; QUINPIROLE;

D O I：

10.1016/0091-3057(92)90463-P

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Male rats were treated with cocaine by utilizing two different experimental paradigms. One group of animals received a low dose (10 mg/kg, IP) of cocaine for 7 days. A second group received 40 m-/kg IP of cocaine for 3 days. In both experimental groups, half the animals were concomitantly treated with 0.25 mg/kg IP (+)-5methyl-10,11-dihydro-5H-di-benzo-[a,d)-cyclohepten-5,10-imine maleate (MK-801), a noncompetitive NMDA receptor antagonist. Rats treated with the low dose of cocaine after 7 days developed tolerance to the stimulation of locomotor activity induced by cocaine and by the dopamine D2 agonist quinpirole. Rats treated with 40 mg/kg of cocaine showed a marked behavioral sensitization. Both these effects, tolerance and sensitization, were prevented by coadministration of MK-801, thus suggesting these two phenomena are different aspects of a common neuronal response in which NMDA transmission plays a crucial role.

引用

页码：179 / 182

页数：4

共 15 条

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