ENZYME ASSISTED SYNTHESIS OF (S)-SOTOLON

被引：9

作者：

FRONZA, G

FUGANTI, C

GRASSELLI, P

PEDROCCHIFANTONI, G

SERVI, S

机构：

[1] Dipartimento di Chimica del Politecnico, CNR Centro per lo Studio delle Sostanze Organiche Naturali, 20133 Milano

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 38期

关键词：

SOTOLON; LIPASE; BAKERS YEAST; RACEMIZATION; DECARBOXYLATION;

D O I：

10.1016/S0040-4039(00)61164-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of enantiomerically enriched sotolon 1 has been studied starting from the racemic precursor 2. Yeast reduction of 2 is diastereoselective, giving access to the corresponding racemic alcohol 3 of anti relative configuration, the acetate of which is resolved into its enantiomers via a lipase catalyzed interesterification with n-butanol. Enantiomerically pure 4 affords (S)-1 of 0.75 ee.

引用

页码：5625 / 5628

页数：4

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