ACTIVATION OF NA+/MG2+ ANTIPORT IN THYMOCYTES BY CAMP

被引：79

作者：

GUNTHER, T

VORMANN, J

机构：

[1] Institute of Molecular Biology and Biochemistry, Free University of Berlin, D- W-1000 Berlin 33

来源：

FEBS LETTERS | 1992年 / 297卷 / 1-2期

关键词：

MAGNESIUM; EFFLUX; CAMP; INTRACELLULAR FREE MG2+; RAT THYMOCYTE;

D O I：

10.1016/0014-5793(92)80343-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mg2+ efflux from Mg2+-loaded rat thymocytes was stimulated by 0.1 mM dibutyryl cAMP (db cAMP). The activation of Mg2+ efflux by db cAMP was more expressed at lower Mg2+-loading. cAMP induced only a very small increase in the concentration of intracellular free Mg2+ which cannot explain the activation of Na+/Mg2+ antiport. From these results it was concluded that cAMP increases the affinity of the Na+/Mg2+ antiporter for intracellular Mg2+, probably by phosphorylation.

引用

页码：132 / 134

页数：3

共 14 条

[1]

BIANCHINI L, 1991, J BIOL CHEM, V266, P15406

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