THE ROLE OF METALLOTHIONEIN, GLUTATHIONE, GLUTATHIONE S-TRANSFERASES AND DNA-REPAIR IN RESISTANCE TO PLATINUM DRUGS IN A SERIES OF L1210 CELL-LINES MADE RESISTANT TO ANTICANCER PLATINUM AGENTS

被引：40

作者：

HRUBISKO, M ^{[1
]}

MCGOWN, AT ^{[1
]}

FOX, BW ^{[1
]}

机构：

[1] CHRISTIE HOSP & HOLT RADIUM INST,NHS TRUST,PATERSON INST CANC RES,CRC,DEPT EXPTL CHEMOTHERAPY,MANCHESTER M20 9BX,LANCS,ENGLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1993年 / 45卷 / 01期

关键词：

D O I：

10.1016/0006-2952(93)90399-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The glutathione contents, glutathione S-transferase activities and metallothionein contents have been measured in a series of L1210 cell lines which show decreased sensitivities to platinum drugs. Resistance to cisplatinum cisDDP, cis-diamminedichloroplatinum (II)] and chip [ioproplatin, cis-dichloro-bis-isopropylamine-trans dihydroxy platinum IV] was found to correlate with glutathione levels but not metallothionein. Conversely, resistance to tetraplatin was found to be correlated with metallothionein but not glutathione levels. However, depletion of glutathione by buthionine 1-sulphoximine sensitizes all cell lines to the effects of cisDDP, chip and tetraplatin [d, 1-trans-tetrachloro-1,2-diamino-cyclohexanplatinum (IV)]. Inhibition of DNA repair by aphidicholin or caffeine also partially restored sensitivity to these platinum drugs. These results indicate the complexity of the changes occurring upon the development of drug resistance.

引用

页码：253 / 256

页数：4

共 14 条

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[2]

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[3]

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[4]

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