IN-VITRO ACTIVITY OF BIAPENEM AGAINST BETA-LACTAMASE-PRODUCING ENTEROBACTERIACEAE

被引：7

作者：

ALONSO, R ^{[1
]}

FDEZARANGUIZ, A ^{[1
]}

COLOM, K ^{[1
]}

MORLA, A ^{[1
]}

SUINAGA, E ^{[1
]}

UMARAN, A ^{[1
]}

CISTERNA, R ^{[1
]}

机构：

[1] HOSP BASURTO,DEPT MICROBIOL,BILBAO,SPAIN

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1994年 / 13卷 / 10期

关键词：

D O I：

10.1007/BF02111342

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The activity of biapenem was compared with that of imipenem and cefotaxime against 108 strains of beta-lactamase producing Enterobacteriaceae. Biapenem and imipenem were very active, inhibiting 90 % of the strains at a concentration of 0.5 mu g/ml. Both carbapenems were very active against plasmidic beta-lactamase producers, with MIC90s below 1 mu g/ml. However, the MIC90 of biapenem for cephalosporinase producers was 1 mu g/ml. Against strains producing extended-spectrum beta-lactamases, biapenem exhibited better activity against TEM-type producers (MIC90 0.25 mu g/ml) than against SHV-type producers (MIC90 0.5 mu g/ml). Overall, the in vitro antibacterial activity of biapenem is similar to that of imipenem.

引用

页码：820 / 822

页数：3

共 7 条

[1] INVITRO ACTIVITY OF L-627, A NEW CARBAPENEM [J].