NEUROTROPHIN-INDUCED MODULATION OF SYNAPTIC TRANSMISSION IN THE ADULT HIPPOCAMPUS

被引：99

作者：

KANG, HJ

SCHUMAN, EM

机构：

[1] Division of Biology 216-76, California Institute of Technology, Pasadena

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1995年 / 89卷 / 01期

关键词：

NEUROTROPHIN; BDNF; NT-3; HIPPOCAMPUS; NEURONAL PLASTICITY;

D O I：

10.1016/0928-4257(96)80547-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The NGF-family of neurotrophic factors including NGF, BDNF and NT-3,4/5 is known to be crucial for neuronal survival and differentiation during development. However, recent studies suggest that the neurotrophins are also widely expressed and play a dynamic role in the mature nervous system. One of the major sites of expression of the neurotrophins in the adult brain is the hippocampus which has been also popular as an important structure for the adult plasticity. Moreover, the level of expression of the neurotrophins in the hippocampus can be regulated by a variety of neuronal inputs, such as experimentally-induced seizures: injection of glutamate receptor agonists, and LTP-inducing stimulation. The possibility that the neurotrophins modulate synaptic transmission in the mature brain has been investigated at the Schaffer collateral-CA1 synapses in the adult rat hippocampus. We report that transient application of BDNF and NT-3, but not NGF induces a long-lasting increase of synaptic transmission, which is likely to be mediated by Trk family of receptor tyrosine kinases. Both BDNF and NT-3 decrease paired pulse facilitation, suggesting a possible presynaptic modification. interestingly, previous potentiation of synaptic activity by the application of neurotrophic factors does not occlode the induction of long-term potentiation. These results suggest that the neurotrophins may locally regulate synaptic plasticity in the adult nervous system.

引用

页码：11 / 22

页数：12

共 57 条

[1]

Ballarin, Ernfors, Lindefors, Persson, Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain, Exp Neurol, 114, pp. 35-43, (1991)

[2]

Barde, Trophic factors and neuronal survival, Neuron, 2, pp. 1525-1534, (1989)

[3]

Bellinger, Madamba, Siggins, Interleukin-1-β inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus, Brain Res, 628, pp. 227-234, (1993)

[4]

Berg, Sternberg, Parada, Chao, K252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity, J Biol Chem, 267, pp. 13-16, (1992)

[5]

Castren, Pitkanen, Sirvio, Parsadanian, Lindholm, Thoenen, Riekkinen, The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus, Neuroreport, 4, pp. 895-898, (1993)

[6]

Chao, Neurotrophin receptors: A window into neuronal differentiation, Neuron, 9, pp. 583-593, (1992)

[7]

Cline, Acticity-dependent plasticity in the visual systems of frogs and fish, Trends Neurosci, 14, pp. 104-111, (1991)

[8]

Collingridge, Kehl, McLennan, Excitatory amino acids in synaptic transmission in the Schaffercollateral commissural pathway of the rat hippocampus, J Physiol (Lond), 334, pp. 33-46, (1983)

[9]

Cordon-cardo, Taply, Jing, Nanduri, O'Rourke, Lamballe, Kovary, Klein, Jones, Rcichardt, Barbacid, The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3, Cell, 66, pp. 173-183, (1991)

[10]

Dragunow, Beilharz, Mason, Lawlor, Abraham, Gluckman, Brainderived neurotrophic factor expression after long-term potentiation, Neurosci Lett, 160, pp. 232-236, (1993)

← 1 2 3 4 5 6 →