SELECTIVE INCREASE OF BRAIN DOPAMINE INDUCED BY GAMMA-HYDROXYBUTYRATE - STUDY OF MECHANISM OF ACTION

被引：134

作者：

GESSA, GL

CRABAI, F

VARGIU, L

SPANO, PF

机构：

[1] Institute of Pharmacology, University of Cagliari

来源：

JOURNAL OF NEUROCHEMISTRY | 1968年 / 15卷 / 05期

关键词：

D O I：

10.1111/j.1471-4159.1968.tb11624.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— γ‐Hydroxybutyrate (γ‐OH) produces a selective accumulation of brain DA not only in normal animals but also in reserpinized animals. This is especially evident after the administration of DOPA; while in parallel experiments γ‐OH does not influence significantly the amount of 5‐HT present in brain after 5‐HTP treatment. γ‐OH does not raise DA in rats after inhibition of tyrosine hydroxylase. The accumulation of brain DA is not due to inhibition of MAO or COMT activity. Copyright © 1968, Wiley Blackwell. All rights reserved

引用

页码：377 / &

共 13 条

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