(+/-)-TRANS-2-(3-METHOXY-5-METHYLSULFONYL-4-PROPOXYPHENYL)-5-(3,4,5-TRIMETHOXYPHENYL)TETRAHYDROFURAN (L-659,989), A NOVEL, POTENT PAF RECEPTOR ANTAGONIST

被引:84
作者
PONPIPOM, MM [1 ]
HWANG, SB [1 ]
DOEBBER, TW [1 ]
ACTON, JJ [1 ]
ALBERTS, AW [1 ]
BIFTU, T [1 ]
BROOKER, DR [1 ]
BUGIANESI, RL [1 ]
CHABALA, JC [1 ]
GAMBLE, NL [1 ]
GRAHAM, DW [1 ]
LAM, MH [1 ]
WU, MS [1 ]
机构
[1] MERCK SHARP & DOHME RES LABS,POB 2000,RAHWAY,NJ 07065
关键词
D O I
10.1016/0006-291X(88)90758-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:1213 / 1220
页数:8
相关论文
共 32 条
[1]  
BENVENISTE J, 1979, CR ACAD SCI D NAT, V289, P1037
[2]  
BENVENISTE J, 1983, INSERM S, V23
[3]   CONFORMATION AND ACTIVITY OF TETRAHYDROFURAN LIGNANS AND ANALOGS AS SPECIFIC PLATELET-ACTIVATING-FACTOR ANTAGONISTS [J].
BIFTU, T ;
GAMBLE, NF ;
DOEBBER, T ;
HWANG, SB ;
SHEN, TY ;
SNYDER, J ;
SPRINGER, JP ;
STEVENSON, R .
JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (10) :1917-1921
[4]  
BIFTU T, 1986, Patent No. 199324
[5]   ANTIHYPERTENSIVE ACTIVITY OF AN ALKYL ETHER ANALOG OF PHOSPHATIDYLCHOLINE [J].
BLANK, ML ;
SNYDER, F ;
BYERS, LW ;
BROOKS, B ;
MUIRHEAD, EE .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 90 (04) :1194-1200
[6]   PAF-ACETHER SPECIFIC BINDING-SITES .2. DESIGN OF SPECIFIC ANTAGONISTS [J].
BRAQUET, P ;
GODFROID, JJ .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1986, 7 (10) :397-403
[7]  
Braquet P.G., 1985, BLOOD VESSELS, V16, P558, DOI [DOI 10.2491/JJSTH1970.16.558, 10.2491/jjsth1970.16.558]
[8]  
CASALSSTENZEL J, 1987, J PHARMACOL EXP THER, V241, P974
[9]  
DEMOPOULOS CA, 1979, J BIOL CHEM, V254, P9355
[10]   PLATELET ACTIVATING FACTOR INTRAVENOUS-INFUSION IN RATS STIMULATES VASCULAR LYSOSOMAL HYDROLASE SECRETION INDEPENDENT OF BLOOD NEUTROPHILS [J].
DOEBBER, TW ;
WU, MS ;
SHEN, TY .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (03) :980-987