Transforming Growth Factor-beta Inhibits Lactogenic Hormone Induction of beta-Casein Expression in HC11 Mouse Mammary Epithelial Cells

被引：43

作者：

Mieth, Maren ^{[1
]}

Boehmer, Frank-D. ^{[1
]}

Ball, Roland ^{[2
]}

Groner, Bernd ^{[2
]}

Grosse, Richard ^{[2
]}

机构：

[1] Acad Sci GDR, Cent Inst Mol Biol, Dept Cell Biol, D-1115 Berlin, Germany

[2] Friedrich Miescher Inst, CH-4002 Basel, Switzerland

来源：

GROWTH FACTORS | 1990年 / 4卷 / 01期

关键词：

Transforming growth factor-beta; mammary epithelial cell; beta-casein expression; inhibition of functional differentiation;

D O I：

10.3109/08977199009011005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HC11 mouse mammary epithelial cells can undergo a limited functional differentiation in terms of beta-casein synthesis in response to the combined action of dexamethasone and prolactin. Transforming growth factor-beta (TGF-beta) can inhibit beta-casein expression in HC11 cells in a dose-dependent manner. This effect is reversible and specific as shown by comparison with the effect of other growth factors. TGF-beta also inhibits DNA synthesis of HC11 cells. These findings suggest a possible role of TGF-beta as an inhibitor of functional differentiation in the mammary gland.

引用

页码：9 / 15

页数：8

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