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THE P53 TUMOR SUPPRESSOR GENE

被引：3926
作者：
LEVINE, AJ
MOMAND, J
FINLAY, CA
机构：
[1] Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton
来源：
NATURE | 1991年 / 351卷 / 6326期
关键词：
D O I：
10.1038/351453a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors. Chief among the negative regulators is the p53 protein. Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of DNA tumour viruses, can lead to cancer. These mutations seem to be the most common genetic change in human cancers.
引用
收藏
页码：453 / 456
页数：4
相关论文
共 61 条
  • [1] SUPPRESSION OF HUMAN COLORECTAL-CARCINOMA CELL-GROWTH BY WILD-TYPE-P53
    BAKER, SJ
    MARKOWITZ, S
    FEARON, ER
    WILLSON, JKV
    VOGELSTEIN, B
    [J]. SCIENCE, 1990, 249 (4971) : 912 - 915
  • [2] BAKER SJ, 1990, CANCER RES, V50, P7717
  • [3] CHROMOSOME-17 DELETIONS AND P53 GENE-MUTATIONS IN COLORECTAL CARCINOMAS
    BAKER, SJ
    FEARON, ER
    NIGRO, JM
    HAMILTON, SR
    PREISINGER, AC
    JESSUP, JM
    VANTUINEN, P
    LEDBETTER, DH
    BARKER, DF
    NAKAMURA, Y
    WHITE, R
    VOGELSTEIN, B
    [J]. SCIENCE, 1989, 244 (4901) : 217 - 221
  • [4] BARTEK J, 1990, ONCOGENE, V5, P893
  • [5] MOUSE P53 INHIBITS SV40 ORIGIN-DEPENDENT DNA-REPLICATION
    BRAITHWAITE, AW
    STURZBECHER, HW
    ADDISON, C
    PALMER, C
    RUDGE, K
    JENKINS, JR
    [J]. NATURE, 1987, 329 (6138) : 458 - 460
  • [6] GENETIC MECHANISMS OF TUMOR SUPPRESSION BY THE HUMAN P53 GENE
    CHEN, PL
    CHEN, YM
    BOOKSTEIN, R
    LEE, WH
    [J]. SCIENCE, 1990, 250 (4987) : 1576 - 1580
  • [7] FREQUENT MUTATIONS IN THE P53 TUMOR SUPPRESSOR GENE IN HUMAN LEUKEMIA T-CELL LINES
    CHENG, J
    HAAS, M
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (10) : 5502 - 5509
  • [8] CHIBA I, 1990, ONCOGENE, V5, P1603
  • [9] SV40 LARGE TUMOR-ANTIGEN FORMS A SPECIFIC COMPLEX WITH THE PRODUCT OF THE RETINOBLASTOMA SUSCEPTIBILITY GENE
    DECAPRIO, JA
    LUDLOW, JW
    FIGGE, J
    SHEW, JY
    HUANG, CM
    LEE, WH
    MARSILIO, E
    PAUCHA, E
    LIVINGSTON, DM
    [J]. CELL, 1988, 54 (02) : 275 - 283
  • [10] DETECTION OF A TRANSFORMATION-RELATED ANTIGEN IN CHEMICALLY-INDUCED SARCOMAS AND OTHER TRANSFORMED-CELLS OF THE MOUSE
    DELEO, AB
    JAY, G
    APPELLA, E
    DUBOIS, GC
    LAW, LW
    OLD, LJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (05) : 2420 - 2424
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