THE ROLE OF HSP90 IN FUNGAL INFECTION

被引：62

作者：

MATTHEWS, R

BURNIE, J

机构：

[1] Ruth Matthews and James Burnie are, the Department of Medical Microbiology, Manchester University Medical School, Manchester, M13 9PT, Oxford Road

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 09期

关键词：

D O I：

10.1016/0167-5699(92)90169-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunodominant antigens of many microbial pathogens are heat shock proteins (hsps). In systemic candidal infections, a major target of protective antibody is an epitope shared with human hsp90. Here, Ruth Matthews and james Burnie suggest that fungal hsp90 plays a key pathogenic role in systemic infection by either binding to certain serum proteins, causing them to malfunction, or by mimicking the functional activity of other proteins.

引用

页码：345 / 348

页数：4

共 42 条

[1] AL-DOORY Y, 1970, Sabouraudia, V8, P41
[2] HSP82 IS AN ESSENTIAL PROTEIN THAT IS REQUIRED IN HIGHER CONCENTRATIONS FOR GROWTH OF CELLS AT HIGHER TEMPERATURES
BORKOVICH, KA
FARRELLY, FW
FINKELSTEIN, DB
TAULIEN, J
LINDQUIST, S
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (09) : 3919 - 3930
[3] SPECIFIC, HIGH-AFFINITY BINDING-SITES FOR HUMAN LUTEINIZING-HORMONE (HLH) AND HUMAN CHORIONIC-GONADOTROPIN (HCG) IN CANDIDA SPECIES
BRAMLEY, TA
MENZIES, GS
WILLIAMS, RJ
ADAMS, DJ
KINSMAN, OS
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 167 (03) : 1050 - 1056
[4] STEROID-HORMONE REGULATION OF THE ACHLYA-AMBISEXUALIS 85-KILODALTON HEAT-SHOCK PROTEIN, A COMPONENT OF THE ACHLYA STEROID-RECEPTOR COMPLEX
BRUNT, SA
RIEHL, R
SILVER, JC
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (01) : 273 - 281
[5] TRANSIENT ABROGATION OF IMMUNOSUPPRESSION IN A PATIENT WITH CHRONIC MUCOCUTANEOUS CANDIDIASIS FOLLOWING VACCINATION WITH CANDIDA-ALBICANS
BURFORDMASON, AP
MATTHEWS, RC
WILLIAMS, JRB
[J]. JOURNAL OF INFECTION, 1987, 14 (02) : 147 - &
[6] HEAT-SHOCK PROTEIN-88 AND ASPERGILLUS INFECTION
BURNIE, JP
MATTHEWS, RC
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (10) : 2099 - 2106
[7] CHILGREN RA, 1967, LANCET, V2, P688
[8] AUTOIMMUNITY, MICROBIAL IMMUNITY AND THE IMMUNOLOGICAL HOMUNCULUS
COHEN, IR
YOUNG, DB
[J]. IMMUNOLOGY TODAY, 1991, 12 (04): : 105 - 110
[9] CUTLER JE, 1976, J RETICULOENDOTH SOC, V19, P121
[10] THE GENOME OF TRYPANOSOMA-CRUZI CONTAINS A CONSTITUTIVELY EXPRESSED, TANDEMLY ARRANGED MULTICOPY GENE HOMOLOGOUS TO A MAJOR HEAT-SHOCK PROTEIN
DRAGON, EA
SIAS, SR
KATO, EA
GABE, JD
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (03) : 1271 - 1275

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