HEPATITIS-B VIRUS-INFECTION MARKERS IN GENETIC HEMOCHROMATOSIS - A STUDY OF 272 PATIENTS

被引:48
作者
DEUGNIER, Y
BATTISTELLI, D
JOUANOLLE, H
GUYADER, D
GUEGUEN, M
LOREAL, O
JACQUELINET, C
BOUREL, M
BRISSOT, P
机构
[1] CTR HOSP REG & UNIV,HOP PONTCHAILLOU,INSERM U49,RENNES,FRANCE
[2] CTR HOSP REG & UNIV,HOP PONTCHAILLOU,CTR REG TRANSFUS SANGUINE,RENNES,FRANCE
关键词
D O I
10.1016/0168-8278(91)90070-R
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Serum hepatitis B virus (HBV) infection markers were studied in 272 patients with homozygous genetic haemochromatosis complicated (n = 33) or not (n = 239) with primary liver cancer (PLC). Controls consisted of 255 029 healthy blood donors from whom age- and sex-matched control groups were extracted for statistical evaluation using the Fisher exact test. In blood donors, HBsAg was positive in 0.075% of males and 0.04% of females. This population was not screened for anti-Hbs. Anti-Hbc alone (without HBsAg) was present in 3.7% of men and 1.8% of women. In patients with genetic haemochromatosis without liver cancer (183 males, 45.6 +/- 11.3 yrs and 56 women, 48 +/- 12.4 yrs), HBsAg was found in 1.1 % of men and in none of the women. Anti-HBs was present in 7.3% of males and 1.8% of females. Anti-HBc alone was found in 13% of males (p < 0.005 vs. controls) and 2.1% of females. From male patients with primary liver cancer complicating genetic haemochromatosis (32 males, 61.7 +/- 6.8 yrs and one female), 6.2% were HBsAg positive, 3.4% were anti-HBs positive and 16.6% anti-HBc positive (p = 0.05 vs. controls). No serum HBV marker was found in the woman. In conclusion, the prevalence of HBV infection markers - especially anti-HBc - is significantly increased in patients with genetic haemochromatosis complicated or not with primary liver cancer.
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页码:286 / 290
页数:5
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