CALCIUM REGULATION IN THE MYOMETRIUM OF PREGNANT SHEEP

被引：5

作者：

CRANKSHAW, DJ

CHALLIS, JRG

PATRICK, JE

DANIEL, EE

机构：

[1] MCMASTER UNIV,HLTH SCI CTR,DEPT NEUROSCI,HAMILTON L8S 4J9,ONTARIO,CANADA

[2] UNIV WESTERN ONTARIO,DEPT OBSTET & GYNECOL,LONDON N6A 3K7,ONTARIO,CANADA

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1979年 / 10卷 / 06期

关键词：

Ca[!sup]2+[!/sup] regulation; Microsomes; Mitochondria; Myometrium; Plasma membrane;

D O I：

10.1159/000299981

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Fractionation of pregnant sheep myometrium has been carried out and the fractions obtained analysed for their marker enzyme content and Ca2+ transporting properties. A fairly pure mitochondrial fraction and a very pure plasma membrane fraction were obtained. Both fractions could accumulate Ca2+ in the presence of ATP but the mechanisms were different, mitochondrial uptake had a high capacity and was inhibited by azide. Plasma membrane uptake was of low capacity and unaffected by azide. The effect of oxalate on plasma membrane suggests that there is an outwardly directed Ca2+ pump in the myometrial cell membrane. Both mitochondria and plasma membrane may be important in the Ca2+ accumulation of relaxation in this muscle. © 1979 S. Karger AG, Basel.

引用

页码：298 / 305

页数：8

共 9 条

[1] STUDIES ON CALCIUM-UPTAKE BY MYOMETRIAL MICROSOMES WITH PARTICULAR REFERENCE TO DEPENDENCE ON INORGANIC-PHOSPHATE AND OXALATE [J].