FACTORS ENHANCING ADHERENCE OF TOXIGENIC STAPHYLOCOCCUS-AUREUS TO EPITHELIAL-CELLS AND THEIR POSSIBLE ROLE IN SUDDEN-INFANT-DEATH-SYNDROME

被引：54

作者：

SAADI, AT ^{[1
]}

BLACKWELL, CC ^{[1
]}

RAZA, MW ^{[1
]}

JAMES, VS ^{[1
]}

STEWART, J ^{[1
]}

ELTON, RA ^{[1
]}

WEIR, DM ^{[1
]}

机构：

[1] UNIV EDINBURGH, SCH MED, DEPT PUBL HLTH SCI, MED STAT UNIT, EDINBURGH EH8 9AG, MIDLOTHIAN, SCOTLAND

来源：

EPIDEMIOLOGY AND INFECTION | 1993年 / 110卷 / 03期

关键词：

D O I：

10.1017/S0950268800050937

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Toxigenic strains of Staphylocccus aureus have been suggested to play a role in sudden infant death syndrome (SIDS). In this study we examined two factors that might enhance binding of toxigenic staphylococci to epithelial cells of infants in the age range in which cot deaths are prevalent: expression of the Lewis(a) antigen and infection with respiratory syncytial virus (RSV). By flow cytometry we demonstrated that binding of three toxigenic strains of S. aureus to cells from nonsecretors was significantly greater than to cells of secretors. Pre-treatment of epithelial cells with monoclonal anti-LeWis(a) or anti-type-1 precursor significantly reduced bacterial binding (P < 0.01); however, attachment of the bacteria correlated only with the amount of Lewis(a) antigen detected on the cells (P < 0.01). HEp-2 cells infected with RSV bound significantly more bacteria than uninfected cells. These findings are discussed in context of factors previously associated with SIDS (mother's smoking, bottle feeding and the prone sleeping position) and a hypothesis proposed to explain some cases of SIDS.

引用

页码：507 / 517

页数：11

共 43 条

[1] INFANT BOTULISM - EPIDEMIOLOGY AND RELATION TO SUDDEN INFANT DEATH SYNDROME [J].