EVALUATION OF [C-11] THYMIDINE FOR MEASUREMENT OF CELL-PROLIFERATION IN FAST DIVIDING TISSUES

被引：16

作者：

POUPEYE, EM

GOETHALS, PP

DAMS, RF

DELEENHEER, AP

VANEIJKEREN, ME

机构：

[1] STATE UNIV GHENT,MED BIOCHEM & KLIN ANAL LAB,HARELBEKESTR 72,B-9000 GHENT,BELGIUM

[2] STATE UNIV GHENT,INST NUCL SCI,ANALYT CHEM LAB,B-9000 GHENT,BELGIUM

[3] STATE UNIV GHENT HOSP,DEPT RADIOTHERAPY & NUCL MED,B-9000 GHENT,BELGIUM

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1993年 / 20卷 / 03期

关键词：

D O I：

10.1016/0969-8051(93)90059-4

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The Purpose of this study was to investigate the possibility of using [C-11]thymidine as a tumor marker for positron emission tomography studies. Biodistribution studies were set up to investigate the in vivo behavior of [C-11]thymidine. Simultaneously, the DNA incorporation in fast dividing tissues and catabolism was studied. Our results confirm that [C-11]thymidine can be used for detection of cell proliferation by positron emission tomography. As such, it can produce supplementary information in cancer research.

引用

页码：359 / 362

页数：4

共 10 条

[1] MECHANISMS RESPONSIBLE FOR LOW INCORPORATION INTO DNA OF THYMIDINE ANALOGUE 5-IODO-2'-DEOXYURIDINE [J].