A NEW CHROMOSOMAL BREAKPOINT IN PH POSITIVE, BCR NEGATIVE CHRONIC MYELOGENOUS LEUKEMIA - REPORT OF A CASE

被引：14

作者：

NEGRINI, M ^{[1
]}

TALLARICO, A ^{[1
]}

PAZZI, I ^{[1
]}

CASTAGNOLI, A ^{[1
]}

CUNEO, A ^{[1
]}

CASTOLDI, GL ^{[1
]}

机构：

[1] UNIV FERRARA,INST HEMATOL,I-44100 FERRARA,ITALY

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 61卷 / 01期

关键词：

D O I：

10.1016/0165-4608(92)90363-D

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a new case of Ph positive chronic myeloid leukemia (CML) without the classical rearrangement in Mbcr. By Southern blot analysis the molecular breakpoint was mapped 3 to 8 kb upstream of Mbcr. This region has not been shown to be rearranged in any other described case of CML. We did not detect any specific abnormal BCR-ABL transcript even with the use of the very sensitive RNA-PCR technique.

引用

页码：11 / 13

页数：3

共 14 条

[1]

ARRUSHDI A, 1988, ONCOGENE, V2, P353

[2]

FAGIOLI F, 1991, IN PRESS CANCER

[3] PHILADELPHIA CHROMOSOMAL BREAKPOINTS ARE CLUSTERED WITHIN A LIMITED REGION, BCR, ON CHROMOSOME-22 [J].