STUDIES ON THE CONSTITUENTS OF FORMOSAN SOLANUM SPECIES .7. CYTOTOXIC PRINCIPLES AND THEIR DERIVATIVES OF FORMOSAN SOLANUM PLANTS

被引：27

作者：

GAN, KH ^{[1
]}

LIN, CN ^{[1
]}

WON, SJ ^{[1
]}

机构：

[1] NATL CHENG KUNG UNIV,COLL MED,DEPT MICROBIOL,TAINAN 701,TAIWAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 01期

关键词：

D O I：

10.1021/np50091a003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The new steroidal alkaloid capsimine-3-0-beta-D-glucoside [1] was isolated from the root bark of Solanum capsicastrum, and carpesterol [2], 3beta-(p-hydroxy)-benzoyloxy-22alpha-hydroxy-4alpha-methyl-5alpha-stigmast-7-en-6-one [3], and a new steroidal glycoside named indioside A [4] were isolated from the fruit of Solanum indicum. Indioside A was characterized as 3beta-O-{alpha-L-rhamnopyranosyl-(1-->2), beta-D-glucopyranosyl-(1-->4), beta-D-glucopyranosyl-(1-->3)-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranosyl)-diosgenin. Khasianine, dihydrosolasodine, capsimine, and capsimine-3-0-beta-D-glucoside exhibited strong activity against liver damage induced by CCl4. Capsimine and narigenin exhibited significant cytotoxic effect against human PLC/PRF/5 and KB cells in vitro, and capsicastrine and etioline exhibited significant cytotoxicity against human PLC/PRF/5 cells in vitro.

引用

页码：15 / 21

页数：7

共 20 条

[1]

AGRAWAL PK, 1989, CARBON 13 NMR FLAVON, P306

[2] SOLANUM ALKALOIDS .114. HAVANINE - A STEROIDAL ALKALOID GLYCOSIDE FROM SOLANUM-HAVANENSE [J].

BASTERECHEA, M ;

PREISS, A ;

COLL, F ;

VOIGT, D ;

MOLA, JL ;

ADAM, G .

PHYTOCHEMISTRY, 1984, 23 (09) :2057-2058

[3] CHEMISTRY OF CARPESTEROL, A NOVEL STEROL FROM SOLANUM-XANTHOCARPUM [J].

BEISLER, JA ;

SATO, Y .

JOURNAL OF ORGANIC CHEMISTRY, 1971, 36 (25) :3946-&

[4]

BUDZIKIEWICZ H, 1964, STRUCTURAL ELUCIDATI, V2, P207

[5]

GERAN RI, 1972, CANC CHEMOTHER REP, V3, P1

[6]

HUNG TY, 1970, J AM CHEM SOC, P7005

[7] MICROASSAY FOR STUDYING ANTICELLULAR EFFECTS OF HUMAN INTERFERONS [J].

ITO, M .

JOURNAL OF INTERFERON RESEARCH, 1984, 4 (04) :603-608

[8]

KANEKO K, 1977, PHYTOCHEMISTRY, V23, P2057

[9]

KUSANO G, 1975, PHYTOCHEMISTRY, V114, P529

[10] STUDIES ON THE CONSTITUENTS OF FORMOSAN SOLANUM SPECIES .6. THE CYTOTOXIC PRINCIPLES OF SOLANUM-INCANUM [J].

LIN, CN ;

LU, CM ;

CHENG, MK ;

GAN, KH ;

WON, SJ .

JOURNAL OF NATURAL PRODUCTS, 1990, 53 (02) :513-516

← 1 2 →