ANTIGEN PRESENTATION, LOSS OF IMMUNOLOGICAL MEMORY AND AIDS

被引：62

作者：

HELBERT, MR ^{[1
]}

LAGESTEHR, J ^{[1
]}

MITCHISON, NA ^{[1
]}

机构：

[1] DEUTSCH RHEUMAFORSCHUNGSZENTRUM, BERLIN, GERMANY

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 07期

关键词：

D O I：

10.1016/0167-5699(93)90232-A

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A key factor causing immunodeficiency in HIV infection seems to be defective antigen presentation. Consequently, CD4+ T-cell populations, initially those expressing CD4SRO, decrease in number not because of their destruction, but because they fail to expand in response to antigenic stimulation. This view implies that it would be mistaken to aim therapies only at correcting T-cell function or preventing infection of T cells.

引用

页码：340 / 344

页数：5

共 41 条

[1] AKBAR AN, 1988, J IMMUNOL, V140, P2171
[2] INTERCONVERSION OF CD45R SUBSETS OF CD4 T-CELLS INVIVO
BELL, EB
SPARSHOTT, SM
[J]. NATURE, 1990, 348 (6297) : 163 - 166
[3] BEVERLEY PCL, 1988, IMMUNOLOGY, P3
[4] BYRNE JA, 1988, J IMMUNOL, V141, P3249
[5] CAMERON PU, 1992, CLIN EXP IMMUNOL, V88, P226, DOI 10.1111/j.1365-2249.1992.tb03066.x
[6] RECONSTITUTION OF LONG-TERM T-HELPER CELL-FUNCTION AFTER ZIDOVUDINE THERAPY IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS
CLERICI, M
LANDAY, AL
KESSLER, HA
PHAIR, JP
VENZON, DJ
HENDRIX, CW
LUCEY, DR
SHEARER, GM
[J]. JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (04) : 723 - 730
[7] CLERICI M, 1991, J IMMUNOL, V146, P2207
[8] DETECTION OF 3 DISTINCT PATTERNS OF T-HELPER CELL DYSFUNCTION IN ASYMPTOMATIC, HUMAN IMMUNODEFICIENCY VIRUS-SEROPOSITIVE PATIENTS - INDEPENDENCE OF CD4+ CELL NUMBERS AND CLINICAL STAGING
CLERICI, M
STOCKS, NI
ZAJAC, RA
BOSWELL, RN
LUCEY, DR
VIA, CS
SHEARER, GM
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (06) : 1892 - 1899
[9] PERIPHERAL-BLOOD MONONUCLEAR CELL ABNORMALITIES AND THEIR RELATIONSHIP TO CLINICAL COURSE IN HOMOSEXUAL MEN WITH HIV INFECTION
DEMARTINI, RM
TURNER, RR
FORMENTI, SC
BOONE, DC
BISHOP, PC
LEVINE, AM
PARKER, JW
[J]. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1988, 46 (02): : 258 - 271
[10] SELECTIVE DEPLETION OF THE OKT 4+ 4B4+ SUBSET IN LYMPH-NODES FROM HIV+ PATIENTS
DEPAOLI, P
CARBONE, A
BATTISTIN, S
CROVATTO, M
ARREGHINI, N
SANTINI, G
[J]. IMMUNOLOGY LETTERS, 1987, 16 (01) : 71 - 73

← 1 2 3 4 5 →