MAPPING OF THE BONE MORPHOGENETIC PROTEIN-1 GENE (BMP1) TO 8P21 - REMOVAL OF BMP1 FROM CANDIDACY FOR THE BONE DISORDER IN LANGER-GIEDION SYNDROME

被引:11
作者
YOSHIURA, K
TAMURA, T
HONG, HS
OHTA, T
SOEJIMA, H
KISHINO, T
JINNO, Y
NIIKAWA, N
机构
[1] KUMAMOTO UNIV,SCH MED,DEPT CHILD DEV,KUMAMOTO 860,JAPAN
[2] KYUNGPOOK NATL UNIV,COLL MED,DEPT ANAT,TAEGU,SOUTH KOREA
来源
CYTOGENETICS AND CELL GENETICS | 1993年 / 64卷 / 3-4期
关键词
D O I
10.1159/000133577
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Fifteen cosmids containing sequences from the human bone morphogenetic protein 1 gene (BMP1) were isolated from a cosmid library. The probe was a 483-bp DNA obtained by the reverse transcriptase-PCR method using primers designed according to the reported BMP 1 sequence. When the positive cosmids were tested for chromosome fluorescence in situ hybridization, all showed signals at 8p21. The results indicated that BMP1 is not responsible for Langer-Giedion syndrome, whose putative gene has been assigned to 8q24.
引用
收藏
页码:208 / 209
页数:2
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