MODULATION OF CORTICAL NEURONAL-ACTIVITY BY A SEROTONERGIC AGENT - A PET STUDY IN HUMANS

被引：42

作者：

KAPUR, S ^{[1
]}

MEYER, J ^{[1
]}

WILSON, AA ^{[1
]}

HOULE, S ^{[1
]}

BROWN, GM ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT PSYCHIAT,TORONTO M5T 1R8,ON,CANADA

来源：

BRAIN RESEARCH | 1994年 / 646卷 / 02期

关键词：

FENFLURAMINE; SEROTONIN; MODULATION; HUMAN; FRONTAL CORTEX; PET;

D O I：

10.1016/0006-8993(94)90091-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study investigates the effect of a serotonergic agent, fenfluramine, on neuronal activity, as measured using [F-18]fluorodeoxyglucose (FDG) uptake with positron emission tomography (PET) in humans. Eleven subjects each received oral fenfluramine and placebo, on two different occasions, followed by FDG PET scans. Our study shows that fenfluramine modulates ongoing neuronal activity in a regionally specific fashion with a relative increase in metabolism in the prefrontal cortex and a relative decrease in the occipital-temporal regions.

引用

页码：292 / 294

页数：3

共 14 条

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