IN-VIVO RELAXATION-TIME MEASUREMENTS ON A MURINE TUMOR-MODEL - PROLONGATION OF T-1 AFTER PHOTODYNAMIC THERAPY

被引：14

作者：

LIU, YH ^{[1
]}

HAWK, RM ^{[1
]}

RAMAPRASAD, S ^{[1
]}

机构：

[1] UNIV ARKANSAS,DEPT ELECTR & INSTRUMENTAT,LITTLE ROCK,AR 72204

来源：

MAGNETIC RESONANCE IMAGING | 1995年 / 13卷 / 02期

关键词：

PHOTODYNAMIC THERAPY; MURINE TUMOR MODEL; RELAXATION TIME; SOLENOID COIL;

D O I：

10.1016/0730-725X(94)00107-E

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

RIF tumors implanted on mice feet were investigated for changes in relaxation times (T-1 and T-2) after photodynamic therapy (PDT). Photodynamic therapy was performed using Photofrin II as the photosensitizer and laser light at 630 nm. A home-built proton solenoid coil in the balanced configuration was used to accommodate the tumors, and the relaxation times were measured before, immediately after, and up to several hours after therapy. Several control experiments were performed using the untreated tumors, tumors treated with Photofrin II alone, or tumors treated with laser light alone. Significant increases in T(1)s of water protons were observed after PDT treatment. In all experiments, P-31 spectra were recorded before and after the therapy to study the tumor status and to confirm the onset of PDT. These studies show significant prolongation of T(1)s after the PDT treatment. The spin-spin relaxation measurements, on the other hand, did not show such prolongation in T-2 values after PDT treatment.

引用

页码：251 / 258

页数：8

共 24 条

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