A CASE OF LIPOPROTEIN GLOMERULOPATHY SUCCESSFULLY TREATED WITH PROBUCOL

被引：28

作者：

AMENOMORI, M ^{[1
]}

HANEDA, M ^{[1
]}

MORIKAWA, J ^{[1
]}

NISHIGAKI, I ^{[1
]}

MAEDA, S ^{[1
]}

HIDAKA, H ^{[1
]}

KIKKAWA, R ^{[1
]}

SHIGETA, Y ^{[1
]}

机构：

[1] KOHOKU GEN HOSP,DEPT INTERNAL MED,KINOMOTO,SHIGA,JAPAN

来源：

NEPHRON | 1994年 / 67卷 / 01期

关键词：

LIPOPROTEIN GLOMERULOPATHY; HYPERLIPOPROTEINEMIA; IMMUNOGLOBULIN A NEPHROPATHY; PROBUCOL;

D O I：

10.1159/000187897

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A 54-year-old woman presented proteinuria and severe hyperlipoproteinemia, She had type III hyperlipoproteinemia with the phenotype E2/2. Renal biopsy specimen revealed lipoprotein thrombi within the glomerular capillary lumina without tubulointerstitial lesion and deposition of IgA in the mesangium and peripheral capillary loops, indicating lipoprotein glomerulopathy with IgA nephropathy. Treatment with probucol resulted in the improvement of both hyperlipoproteinemia and proteinuria with the disappearance of the lipoprotein thrombi in the glomerular capillary without any change in the mesangial IgA deposition. The data suggest that probucol may be effective against the early stage of lipoprotein glomerulopathy with less lipoprotein thrombi and without tubulointerstitial damage.

引用

页码：109 / 113

页数：5

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