A NOVEL AMINO ACID-BINDING RECEPTOR-BASED ON WEAK NONCOVALENT LIGAND-LIGAND INTERACTIONS

被引:18
作者
JITSUKAWA, K [1 ]
MORIOKA, T [1 ]
MASUDA, H [1 ]
OGOSHI, H [1 ]
EINAGA, H [1 ]
机构
[1] KYOTO UNIV,FAC ENGN,DEPT SYNTHET CHEM,SAKYO KU,KYOTO 606,JAPAN
关键词
CRYSTAL STRUCTURES; COBALT COMPLEXES; AMINO ACID COMPLEXES; MOLECULAR RECOGNITION;
D O I
10.1016/0020-1693(93)03715-M
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The Co(III) complex with the (N)(O)3-type tripodal tetradentate ligand, bis-NN-carboxymethyl-L-phenylalanine (BCMPA, H-3bcmpa), can site-specifically coordinate a bidentate amino acid (AA, Haa) in the trans-N configuration rather than the cis-N form through the non-covalent weak interligand interactions of hydrogen bondings, steric repulsion, and electrostatic repulsion, on the basis of the H-1 NMR spectroscopic data and X-ray crystallographic analysis. In addition, the [Co(bcmpa)(aa)]- complex with cis-N form isomerizes to the trans-N form, which confirms that the trans-N complex is thermodynamicaily more stable than the cis-N one. These interactions between the coordination sites of bcmpa and aa ligands are of interest as a molecular recognition model for the enzyme(bcmpa)-substrate(aa) complex.
引用
收藏
页码:249 / 251
页数:3
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