MINOXIDIL (MX) AS A PROPHYLAXIS OF DOXORUBICIN - INDUCED ALOPECIA

被引：41

作者：

RODRIGUEZ, R

MACHIAVELLI, M

LEONE, B

ROMERO, A

CUEVAS, MA

LANGHI, M

ACUNA, LR

ACUNA, JR

AMATO, S

BARBIERI, M

VALLEJO, C

RABINOVICH, M

PEREZ, J

SABATINI, C

ORTIZ, E

SALVADORI, M

LACAVA, J

机构：

[1] Grupo Oncológico Cooperativo del Sur (G.O.C.S.), Neuquén

来源：

ANNALS OF ONCOLOGY | 1994年 / 5卷 / 08期

关键词：

ALOPECIA; MINOXIDIL; DOXORUBICIN; CHEMOTHERAPY;

D O I：

10.1093/oxfordjournals.annonc.a058986

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Minoxidil (Mx) is known to induce hair growth in men with male-pattern baldness. Based on this potential, the effectiveness of Mx 2% topical solution was evaluated in cancer patients (pts) to prevent doxorubicin-induced alopecia. Patients and methods: 48 female pts with different types of solid tumors treated with doxorubicin-based chemotherapy in a dose range of 50-60 mg/m2/cycle were randomly assigned to receive Mx 2% topical solution or placebo. Results: 88% and 92% of pts in both arms showed severe alopecia (p = ns). No adverse effects were observed. Conclusion: In this study Mx 2% topical solution was non-toxic but was not effective in the prevention of chemotherapy-induced alopecia.

引用

页码：769 / 770

页数：2