Clofibrate treatment increases stearoyl-CoA desaturase mRNA level and enzyme activity in mouse liver

被引：19

作者：

Diczfalusy, U ^{[1
]}

Eggertsen, G ^{[1
]}

Alexson, SEH ^{[1
]}

机构：

[1] HUDDINGE UNIV HOSP,KAROLINSKA INST,DIV CLIN CHEM,DEPT MED LAB SCI & TECHNOL,S-14186 HUDDINGE,SWEDEN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM | 1995年 / 1259卷 / 03期

关键词：

Delta(9)-desaturase; peroxisome proliferator; transcriptional regulation; brown adipose tissue;

D O I：

10.1016/0005-2760(95)00185-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stearoyl-CoA desaturase activity is encoded by two highly homologous genes, SCD1 and SCD2, which show tissue-specific expression and regulation. SCD1, which is expressed in the Liver, showed a marked diurnal variation with the highest expression during the feeding period. Treatment of mice with the peroxisome proliferator clofibrate, which induces several lipid metabolizing enzymes, increased both the enzyme activity and mRNA level in the liver, indicating regulation at the transcriptional level. The highest expression of both SCD1 and SCD2 was found in brown adipose tissue, which was slightly down-regulated by feeding a fat-free diet.

引用

页码：313 / 316

页数：4

共 20 条

[1]

ALEXSON SEH, 1994, J BIOL CHEM, V269, P17118

[2]

AUFFRAY C, 1980, EUR J BIOCHEM, V107, P303

[3] INTRACELLULAR LOCALIZATION OF ENZYMATIC DEFECT OF LIPID METABOLISM IN DIABETIC RATS [J].