THE SWI SNF COMPLEX - A CHROMATIN REMODELING MACHINE

被引：347

作者：

PETERSON, CL

TAMKUN, JW

机构：

[1] UNIV MASSACHUSETTS,MED CTR,DEPT BIOCHEM & MOLEC BIOL,WORCESTER,MA 01605

[2] UNIV CALIF SANTA CRUZ,DEPT BIOL,SANTA CRUZ,CA 95064

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 04期

关键词：

D O I：

10.1016/S0968-0004(00)88990-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The SWI-SNF complex plays a key role in the regulation of eukaryotic gene expression. Genetic studies in the yeast Saccharomyces cerevisiae suggest that one role for the complex is to antagonize chromatin-mediated repression of transcription. Recent biochemical studies indicate that S. cerevisiae and putative human SWI-SNF complexes use the energy of ATP hydrolysis to disrupt nucleosome structure.

引用

页码：143 / 146

页数：4

共 27 条

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