CHOLINERGIC STIMULATION IN HEART OF MOLLUSC TAPES WATLINGI

1. 1. On the heart of the mollusc Tapes watlingi acetylcholine produces cardiac inhibition, and in the presence of benzoquinonium, cardiac excitation. 2. 2. The excitation consists of a positive inotropic effect which is often associated with a negative chronotropic effect. 3. 3. Acetylcholine still induces cardiac excitation in the presence of several techniques shown to produce denervation". 4. 4. It is concluded that the acetylcholine-induced excitation is a direct effect on the heart muscle and is independent of any nerve supply. © 1969."