PHARMACOLOGICAL EFFECTS OF PANICULATIN - A GLYCOSIDE ISOLATED FROM IPOMOEA DIGITATA LINN

被引：6

作者：

MATIN, MA

TEWARI, JP

KALANI, DK

机构：

[1] Department of Pharmacology, G.S.V.M. Medical College, Kanpur, Uttar Pradesh

[2] National Botanic Gardens, Lucknow, Uttar Pradesh

[3] Industrial Toxicology Research Centre, Lucknow, Uttar Pradesh, Chattar Manzil Palace

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 06期

基金：

美国国家卫生研究院;

关键词：

LD[!sub]50[!/sub] value—paniculatin; Paniculatin—Ipomoea digitata glycoside; Pharmacological screening—paniculatin;

D O I：

10.1002/jps.2600580625

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A glycoside (paniculatin), m.p. 134°, C30H54O13 has been isolated from the tubers of Ipomoea digitata Linn. It elevated the blood pressure, showed a stimulant effect on myocardium and respiration, a vasoconstrictor and bronchoconstrictor effect, a spasmogenic effect on smooth muscles of gut, and also an oxytocic activity. The LD50 (48 hr.), with 95% fiducial limits, was found to be 867.4 (755.3–985.1) mg./kg. (SE ± 1.03) intraperitoneally in mice. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：757 / &

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MISHRA, SS ;

TEWARI, JP ;

MATIN, MA .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (03) :471-&

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