INACTIVATION OF VIRAL-ANTIGENS FOR VACCINE PREPARATION WITH PARTICULAR REFERENCE TO THE APPLICATION OF BINARY ETHYLENIMINE

被引：158

作者：

BAHNEMANN, HG

机构：

[1] Pan American Foot-and-Mouth Disease Center, Pan American Health Organization-WHO, 20001 Rio de Janeiro

来源：

VACCINE | 1990年 / 8卷 / 04期

关键词：

binary ethylenimine; Inactivation; viral antigens;

D O I：

10.1016/0264-410X(90)90083-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viral antigens for human and veterinary vaccines are still inactivated with formaldehyde. This is not an ideal inactivant and the problems of formaldehyde inactivation of vaccines are discussed. Vaccines inactivated with aziridines are superior in safety and antigenicity. Aziridines inactivate viruses in a first-order reaction and the inactivation rate and endpoint can be determined. The preparation and application of the aziridine compound binary ethylenimine (BEI) and the necessary conditions for and controls of the inactivation process are described and discussed. A computer program has been written for assistance in the use of BEI for controlled inactivation of viral antigens. © 1990.

引用

页码：299 / 303

页数：5

共 45 条

[1]

ALONSO A, 1975, B CPFA, P17

[2]

ALONSO A, 1988, IN PRESS B CPFA, V54, P53

[3]

BAHNEMAN HG, 1987, MODERN APPROACHES AN

[4]

BAHNEMANN HG, 1976, J CLIN MICROBIOL, V3, P209