ROLE OF PLASMA-MEMBRANE DEFECT OF SKELETAL-MUSCLE IN MALIGNANT HYPERTHERMIA

被引：64

作者：

GALLANT, EM

GODT, RE

GRONERT, GA

机构：

[1] MED COLL GEORGIA, DEPT PHYSIOL, AUGUSTA, GA 30901 USA

[2] MAYO CLIN & MAYO FDN, DEPT PHARMACOL, ROCHESTER, MN 55901 USA

[3] MAYO CLIN & MAYO FDN, DEPT ANESTHESIOL, ROCHESTER, MN 55901 USA

来源：

MUSCLE & NERVE | 1979年 / 2卷 / 06期

关键词：

D O I：

10.1002/mus.880020610

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Halothane, at clinical concentrations, depolarizes the plasma membrane of skeletal muscle from Poland China pigs susceptible to malignant hyperthermia but does not affect the resting membrane potential of muscle from normal Poland China pigs, mice or frogs. The depolarization is reduced or partially reversed in the presence of dantrolene sodium. Malignant hyperthermia may be initiated by this abnormal depolarization of skeletal muscle by halothane.

引用

页码：491 / 494

页数：4

共 27 条

[1]

ALDRETE JA, 1978, 2ND INT S MAL HYP NE, P103

[2]

ANDERSON IL, 1978, 2ND INT S MAL HYP, P509

[3] CLINICAL, ELECTROPHYSIOLOGICAL AND PATHOLOGICAL-STUDIES ON MALIGNANT HYPERPYREXIA [J].