EXPRESSION OF THE PP63 GENE ENCODING THE INSULIN-RECEPTOR TYROSINE KINASE INHIBITOR IN PROLIFERATING LIVER AND IN LIVER-TUMORS

被引：4

作者：

COLOMBO, BM

FALQUERHO, L

MANENTI, G

DRAGANI, TA

LECAM, A

机构：

[1] IST NAZL TUMORI,DIV EXPTL ONCOL A,I-20133 MILAN,ITALY

[2] CNRS,PHARMACOL ENDOCRINOL LAB,F-34033 MONTPELLIER,FRANCE

[3] INSERM,F-34100 MONTPELLIER,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 180卷 / 02期

关键词：

D O I：

10.1016/S0006-291X(05)81160-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

After partial hepatectomy in rats, a ≈4-fold decrease in pp63 mRNA level was detected at 24h, but not at earlier time points. In mice, during liver cell proliferation induced by 1,4-bis[2-(3,5-dichloropyridyloxy) ]benzene and phenobarbital, pp63 transcript levels had a decrease of 40-50%. However, pp63 mRNA was 5-6 fold higher in murine hepatocellular tumors than in normal adult mouse liver. © 1991 Academic Press, Inc.

引用

页码：967 / 971

页数：5

共 17 条

[1] CHARACTERIZATION OF A NATURAL INHIBITOR OF THE INSULIN-RECEPTOR TYROSINE KINASE - CDNA CLONING, PURIFICATION, AND ANTI-MITOGENIC ACTIVITY [J].